#2813 INCREASED RISK OF CARDIOVASCULAR DISEASE PRECEDING DIAGNOSIS OF INCIDENT ANCA-ASSOCIATED VASCULITIS: A DANISH NATIONWIDE STUDY
نویسندگان
چکیده
Abstract Background and Aims ANCA-associated vasculitis (AAV) is associated with an increased risk of cardiovascular disease (CVD). The CVD seems to be shortly after initial diagnosis as well in the long-term setting. However, no studies have addressed period preceding AAV diagnosis. Since often a substantial diagnostic delay, we hypothesize that patients consistently are at developing already before they even diagnosed AAV. Method Using nested case-control framework, were identified through Danish Nationwide Registries from 1996-2021 matched 1:3 age- sex-matched controls without Each control was assigned same index date (date AAV-diagnosis) their corresponding case. Conditional logistic regression used compute age, sex comorbidity adjusted Hazard Ratios (HRs) for major adverse events (MACE), ischemic heart disease, failure, venous thromboembolism, atrial fibrillation, stroke, pericarditis, ventricular arrhythmias/ICD-implantation/cardiac arrest (VA/ICD/CA) within 12 months, 6 3 2 months 1 month date. Results A total 2371 (median age: 63 yrs, 53.7% male) 7113 controls. In AAV, 10.33% had outcome compared 3.84% (HR 3.05 [95% CI, 2.48-3.75]). outcomes similarly temporal proximity diagnosis, highest HR prior 10.73 7.05-16.32], Fig. 1). individual analysis, significantly higher observed all (excluding VA/ICD/CA), 2. Conclusion which underlines importance early clinical vigilance toward starting phase
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2023
ISSN: ['1460-2385', '0931-0509']
DOI: https://doi.org/10.1093/ndt/gfad063c_2813